Clinical Evidence & Research

This comprehensive meta-analysis of data from 607 patients revealed that men receiving shockwave therapy were six times more likely to achieve restored erectile function than placebo groups.

Meta-analysis of randomized controlled trials that assess the efficacy of low-intensity shockwave therapy for the treatment of erectile dysfunction

Campbell, J. D., Trock, B. J., Oppenheim, A. R., Anusionwu, I., Gor, R. A., & Burnett, A. L. (2019).

Therapeutic Advances in Urology, 11.

A review of 11 studies confirmed significant improvements in 799 patients 6 months after initial treatment, with improved function sustained 12 months after treatment, even despite some evidence of “a small gradual decline.”

A systematic review of the long-term efficacy of low-intensity shockwave therapy for vasculogenic erectile dysfunction — beyond the abstract.

Brunckhorst O., Wells L., Teeling F., Muir G., Muneer A., & Ahmed K. (2019).

International urology and nephrology.

Based on 1, 3, and 6-month follow-ups after shockwave therapy treatment, 81% of participants reported a successful treatment.

Initial experience with linear focused shockwave treatment for erectile dysfunction: a 6-month follow-up pilot study

Reisman Y., Hind A., Varaneckas A., & Motil I. (2015).

International Journal of Impotence Research.

This controlled study demonstrates that shockwave therapy can restore medication responsiveness in men previously resistant to treatment, increasing sensitivity to PDE5i drugs.

Penile Low Intensity Shock Wave Treatment is Able to Shift PDE5i Nonresponders to Responders: A Double-Blind, Sham Controlled Study

Kitrey N.D., Gruenwald I., Appel B., Shechter A., Massarwa O., & Vardi Y. (2016).

Journal of Urology.

This study of men who haven’t responded to ED medication despite maximum doses found that shockwave therapy resulted in improvements in erectile function in 67.3% of participants.

Low-Intensity Extracorporeal Shockwave Therapy Can Improve Erectile Function in Patients Who Failed to Respond to Phosphodiesterase Type 5 Inhibitors

Tsai CC., Wang CJ., Lee YC., Kuo YT., Lin HH., Li CC., Wu WJ., & Liu CC. (2017).

American Journal of Men's Health, 11(6), 1781.

Researchers found that low-intensity shockwaves activate stem cells in penile tissue, presenting an alternative to therapy that introduces stem cells into the penile tissue from outside sources.

In Situ Activation of Penile Progenitor Cells With Low-Intensity Extracorporeal Shockwave Therapy

Lin G., Reed-Maldonado A.B., Wang B., Lee YC., Zhou J., Lu Z., Wang G., Banie L., & Lue T.F. (2017).

The Journal of Sexual Medicine, Volume 14, Issue 4

Researchers found a substantial increase in penile blood flow velocity following shockwave therapy treatment, revealing measurable physiological improvements.

The role of low-intensity shock wave therapy on erectile dysfunction

de Oliveira, P. S., de Oliveira, T. R., Martins, F., & Lopes, T. (2018).

The Journal of Sexual Medicine, Vol. 15, Issue Supplement_3

Researchers captured measurable changes in penile tissue physiology and blood flow patterns following shockwave therapy, confirming physiological improvements rather than just symptom relief.

Efficiency Assessment of Shock Wave Therapy in Patients with Pelvic Pain Employing Harmonic Analysis of Penile Bioimpedance

Khodyreva, L. A., Dudareva, A. A., Mudraya, I. S., Markosyan, T. G., Revenko, S. V., Kumachev, K. V., & Logvinov, L. A. (2013).

Bulletin of Experimental Biology and Medicine, Vol. 155, No. 2

Researchers found that more shockwave therapy sessions produced better results (62% success with 6 sessions, 74% with 12 sessions, and 83% with 18 sessions).

Development of an evidence-based protocol for the application of low-intensity shockwave therapy for erectile dysfunction: comparison of two treatment protocols and the impact of repeating treatment

Kalyvianakis, D., Memmos, E., Mykoniatis, I., Kapoteli, P., Memmos, D., & Hatzichristou D. (2018).

The Journal of Sexual Medicine, Volume 15, Issue Supplement_3

Researchers found that all patients experienced significant improvements regardless of whether they had experienced erectile dysfunction for more or less than 24 months.

Low-intensity shock wave therapy for erectile dysfunction and the influence of disease duration.

de Oliveira, P. S., de Oliveira, T. R., Nunes, Álvaro, Martins, F., & Lopes, T. (2019)..

Archivio Italiano Di Urologia E Andrologia, 90(4)

This meta-analysis provides evidence that TRT effectively improves erectile function without negatively affecting prostate health or urinary function, regardless of how it’s administered.

An updated systematic review and meta-analysis of the effects of testosterone replacement therapy on erectile function and prostate

Xu, Z., Chen, X., Zhou, H., Ren, C., Wang, Q., Pan, Y., Liu, L., & Liu, X. (2024).

Frontiers in Endocrinology, 15, 1335146.

This comprehensive meta-analysis analyzed data from 3,431 men across 17 trials, finding that TRT produced clinically significant benefits and improved quality of life measures, particularly for aging males.

Symptomatic benefits of testosterone treatment in patient subgroups: a systematic review, individual participant data meta-analysis, and aggregate data meta-analysis

Hudson, Jemma, Cruickshank, Moira, Quinton, Richard, Aucott, Lorna, Wu, Frederick, Grossmann, Mathis, et al. (2023).

The Lancet Healthy Longevity, Volume 4, Issue 10

Investigating patient satisfaction following TRT, this study found that 70% of men with low testosterone were satisfied with treatment when considering experience and outcomes.

Efficacy of testosterone replacement treatment for patients with symptoms of late-onset hypogonadism based on real-world patient satisfaction

Ishikawa, Keisuke, Tsujimura, Akira, Miyoshi, Miho, Miyoshi, Yuto, Ogasa, Taiki, Hiramatsu, Ippei, Uesaka, Yuka, Nozaki, Taiji, Shirai, Masato, Kobayashi, Kazuhiro, & Horie, Shigeo (2023).

Endocrine Journal, Volume 70, Issue 9

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